The effective factors in human-specific tropism and viral pathogenicity in orthopoxvirusesReview Published on 2023-02-012023-06-10 Journal: Cell biology international [Category] 원숭이두창, [키워드] Monkeypox orthopoxviruses tropism Viral pathogenicity. [DOI] 10.1002/cbin.11941 PMC 바로가기 [Article Type] Review
Intranasal administration of a virus like particles-based vaccine induces neutralizing antibodies against SARS-CoV-2 and variants of concern입자 기반 백신과 같은 바이러스의 비강 투여는 SARS-CoV-2 및 우려되는 변이체에 대한 중화 항체를 유도합니다.Article Published on 2022-08-012022-09-11 Journal: Allergy [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] administration Aerosols antibody antibody response against candidate vaccine Cell clinical trial contagious COVID-19 displaying elicited epitope evaluated help helper cell IgA antibodies IgA antibody immune response immunogenicity induce intranasal ligands local immune response lung tissue maintain Mask Masks mucosal mucosal immune murine model neutralize neutralizing antibody plasma Plasma cell platform Protective RBD RBD of SARS-CoV-2 recognize reduce required respiratory respiratory droplet Respiratory droplets SARS-CoV-2 Seven systemic and local T helper cell TLR7 TLR7/8 Transmission transmitted tropism tropism of SARS-CoV-2 Vaccine vaccine platform Vaccines variants of concern Viral viral shedding virus Virus-like particle virus-like particles virus-like particles. VLPs VOCs [DOI] 10.1111/all.15311 PMC 바로가기 [Article Type] Article
Suppression of Pituitary Hormone Genes in Subjects Who Died From COVID-19 Independently of Virus Detection in the Gland샘에서 바이러스 검출과 독립적으로 COVID-19로 사망한 피험자의 뇌하수체 호르몬 유전자 억제Article Published on 2022-07-142022-09-11 Journal: The Journal of Clinical Endocrinology and Metaboli [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] ACTH adrenocorticotropic adrenocorticotropic hormone Antigen antigens cardiac death Cell Chain Reaction changes in clinically controls COVID-19 COVID-19 case COVID-19 group cytotoxic cell death deficiency detection died direct viral infection dysfunction evaluate exploration expression Gene Expression Genes gland hormone Hormones hospitalized patients hypophysis immune immunohistochemistry In situ hybridization investigated Involvement Level mRNA transcript mRNA transcripts neurohypophysis neutrophil Patient PCR Pituitary pituitary apoplexy pituitary gland pituitary hormone pituitary hormones. polymerase chain polymerase chain reaction Real-Time Reverse Transcription Polymerase Chain Reaction reverse transcription SARS-CoV-2 SARS-CoV-2 genome SARS-COV-2 infection searched serum severe COVID-19 Signaling subject sudden cardiac death suggested Support suppressed suppression the SARS-CoV-2 genome transmission electron microscopy trauma tropism tropism of SARS-CoV-2 type I interferon Viral viral genome viral infection virus were measured [DOI] 10.1210/clinem/dgac312 PMC 바로가기 [Article Type] Article
Multisystem screening reveals SARS-CoV-2 in neurons of the myenteric plexus and in megakaryocytes다중 시스템 스크리닝은 myenteric plexus의 뉴런과 거핵 세포에서 SARS-CoV-2를 나타냅니다Article Published on 2022-06-012022-09-11 Journal: The Journal of pathology [Category] COVID19(2023년), SARS, 치료법, [키워드] ACE2 expression affected Analysis average biopsy Bone marrow causative agent Cell cellular tropism Chain Reaction clinical symptom Clinical symptoms Complete complications of COVID-19 Concordance controls COVID-19 cytoplasmic death digestive disease enteric nervous system entry receptor exceeded followed by gastrointestinal tract Great Britain histological immunohistochemistry increasingly Ireland journal megakaryocytes monoclonal antibody Multiorgan myenteric plexus nervous system Neuron neurons nucleocapsid protein organ pandemic parkinson s disease Parkinson's Disease pathological pathology Patient patients PCR swab performed Platelet polymerase chain polymerase chain reaction Respiratory illness reveal SARS-CoV-2 Society Son staining symptom onset the SARS-CoV-2 thrombotic Thrombotic events Thrombus thrombus formation time of death tissue tracheal tropism tropism of SARS-CoV-2 tropism. Ventilation widespread [DOI] 10.1002/path.5878 PMC 바로가기 [Article Type] Article
From Deer-to-Deer: SARS-CoV-2 is efficiently transmitted and presents broad tissue tropism and replication sites in white-tailed deer사슴에서 사슴으로: SARS-CoV-2는 효율적으로 전염되며 흰꼬리사슴의 광범위한 조직 친화성과 복제 부위를 나타냅니다.Article Published on 2022-03-212022-09-11 Journal: PLoS Pathogens [Category] SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus added age Americas B.1 lineage causative agent Central nervous system Contact coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Critical deer demonstrated disease disease control effective host range humans hunting implementation infect Infection Infectious virus intranasal investigated lack lymphoid Measures nasal natural infection Odocoileus Prevent provide replication site reported reservoir SARS-CoV-2 SARS-CoV-2 replication severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shown susceptible tissue tropism tissues Transmission Transmission dynamics transmitted tropism Viral load virus virus replication white-tailed deer wild animal zoonotic transmission [DOI] 10.1371/journal.ppat.1010197 PMC 바로가기 [Article Type] Article
SARS-CoV-2: Receptor and Co-receptor Tropism ProbabilitySARS-CoV-2: 수용체 및 공동 수용체 방향성 확률Review Published on 2022-03-162022-09-11 Journal: Current microbiology [Category] SARS, 유전자 메커니즘, [키워드] ACE2 ACE2 distribution acute respiratory syndrome addition Amino acid amino acids angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 attachment binding broad spectrum caused cells cellular cellular component China Co-receptor coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 disease domain entry of SARS-CoV-2 extreme facilitate Factor first stage help heterogeneous Host host cell hosts humans infect mechanisms membrane molecular organs pandemic Pathogenesis pathogenesis of COVID-19 pathogenic virus Perspective Prevent protease Proteases public health RBD receptor Receptor-binding domain receptor-binding domains receptors required SARS-CoV-2 SARS-CoV-2 spike protein Severe acute respiratory syndrome Severe acute respiratory syndrome-related coronavirus Severe acute respiratory syndrome-related coronavirus-2 severity Spike protein Spike proteins susceptibilities the SARS-CoV-2 the spike protein tissues Treatment strategies tropism understanding virus entry [DOI] 10.1007/s00284-022-02807-7 PMC 바로가기 [Article Type] Review
Fatal Neurodissemination and SARS-CoV-2 Tropism in K18-hACE2 Mice Is Only Partially Dependent on hACE2 ExpressionK18-hACE2 마우스의 치명적인 신경 보급 및 SARS-CoV-2 향성은 hACE2 발현에 부분적으로만 의존합니다Article Published on 2022-03-052022-09-11 Journal: Viruses [Category] SARS, 치료기술, [키워드] ACE2 ACE2 protein ACE2-expressing cell ACE2-expressing cells Analysis angiotensin animal animal models AT1 axonal transport blood-brain barrier Brain bronchiolar Cell Cohort comparative pathology COVID-19 Critical cytokeratin cytokeratin 18 promoter days post-infection death Dependent detectable dose ENhance epidemiological data euthanasia evaluated Evidence expressing expression hACE2 Human human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 hypothermia immunohistochemistry In situ hybridization in vivo in vivo imaging independent independent of inoculated intranasal K18-hACE2 Lineage Mild-to-moderate neuroepithelium Neuron neurons occur olfactory olfactory bulb olfactory neuroepithelium overexpression pathologic PFUs Pneumocytes Pneumonia portal question resulting SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pathogenesis spatiotemporal subsequent transgenic mice translational translational animal model Transmission transmission electron microscopy Transport tropism vasculature viral pathogenesis Viral pathogenesis. Viremia Virological [DOI] 10.3390/v14030535 PMC 바로가기 [Article Type] Article
Multiorgan and Vascular Tropism of SARS-CoV-2SARS-CoV-2의 다기관 및 혈관 친화성Case Reports Published on 2022-03-032022-09-11 Journal: Viruses [Category] SARS, 치료기술, 치료제, [키워드] active viral replication adrenal gland Affect biopsies contribute COVID-19 COVID-19 patient deep sequencing distribution favor Genetic heterogeneous highlight histological Infection Inferior vena cava Intra-host variability investigated lower respiratory system multiple tissues Mutation organ organs other tissue other tissues pancreas Post-mortem Quasispecies respiratory tract RNA transcript SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 mutation SARS-CoV-2 mutations Sequencing specimen Spike protein stomach the SARS-CoV-2 the spike protein tissue tissues tropism ultra-deep sequencing Variability vena Viral quasispecies viral quasispecies. Virological was performed [DOI] 10.3390/v14030515 PMC 바로가기 [Article Type] Case Reports
Molecular consequences of SARS-CoV-2 liver tropismSARS-CoV-2 간 친화성의 분자적 결과Article Published on 2022-03-012022-09-11 Journal: Nature metabolism [Category] MERS, SARS, 유전자 메커니즘, 진단, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Affect Analysis Autopsy Clinical outcome clinical outcomes cohorts of patient consequence coronavirus COVID-19 Evidence Extrapulmonary Frequency heart histopathological Hospitalization human liver identify increase independent indicated Isolation kidney liver liver function tests Liver injury liver tissue manifestation molecular organ-specific organs patient cohort pharmacological potential long-term sequelae profile proteomic respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe COVID-19 similarities similarity specimens targets Transcription transcription factor tropism tropism of SARS-CoV-2 Viral viral infection viral infections Viral RNA viral RNA detection with COVID-19 [DOI] 10.1038/s42255-022-00552-6 PMC 바로가기 [Article Type] Article
Systems analysis shows that thermodynamic physiological and pharmacological fundamentals drive COVID‐19 and response to treatmentReview Published on 2022-02-012023-06-14 Journal: Pharmacology Research & Perspectives [Category] COVID19(2023년), MERS, SARS, [키워드] ACE2 affinity complex systems COVID‐19 Dissociation constant Gibbs free energy Innate immunity Kinetics law of mass action MERS pandemic Pharmacology Physiology renin angiotensin system SARS‐CoV‐1 SARS‐CoV‐2 Thermodynamics tropism variants virus [DOI] 10.1002/prp2.922 PMC 바로가기 [Article Type] Review